Published March 28, 1984
by John Wiley & Sons Inc .
Written in English
|The Physical Object|
|Number of Pages||768|
This book is absolutely the most comprehensive and well written book in this field. The pictures are astounding, and the layout is superb. The whole book is great but, the chapters written by G. C. Walker are particularly enlightening. Anyone with even a mild intrest in DNA Repair and or Mutagenesis should purchase this book with utmost by: Volume 10 of Cellular Responses to DNA Damage: Proceedings of the UCLA Symposia Conference Held in Keystone, Colorado, April , , Errol C. Friedberg Volume 11 of UCLA symposia on molecular and cellular biology, Symposium on Molecular and Cellular Biology, ISSN Author: Errol C. Friedberg: Editors: Errol C. Friedberg, B. A. Bridges. The cellular responses to DNA damage The ability to survive spontaneous and induced DNA damage, and to minimize the number of heritable mutations that this causes, is essential to the maintenance ofgenome integrity for all organisms. Early studies on model eukaryotes focused on genes acting in. Featuring more t references and a text lavishly complemented by over illustrations, DNA Repair and Mutagenesis, 2nd Edition, is a timely update to the original edition published in The addition of three new authors, including an expert in the field of structural biology, ensures a comprehensive review of the most current research in diverse subject areas.
Cells with reduced ability to undergo apoptosis in response to DNA damage would tend to accumulate mutations when replication occurs past those damages, and such cells may give rise to colon cancers. In addition, 7 epidemiological studies between and (reviewed by Bernstein et al. [ 54 ]), found that fecal bile acid concentrations are. Responses to Aberrant DNA Replication and DNA Damage in Metazoa Jean Gautier and Jiri Bartek: CELLULAR DNA REPLICATION AND HUMAN DISEASE: DNA Damage and Human Disease Errol C. Friedberg: DNA Polymerases and the Fidelity of DNA Replication Polina V. Shcherbakova and Thomas A. Kunkel: A dedicated DNA damage response (DDR) is therefore essential to maintain genome integrity at these exposed regions. The DDR is a complex network involving DNA damage sensor proteins, such as the poly(ADP-ribose) polymerase 1 (PARP-1), the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the ataxia–telangiectasia-mutated (ATM. The MTH1 proteins sanitize oxidized dNTPs from the dNTP pool to prevent oxidative DNA damage being incorporated into cancer cells. 93 Potent MTH1 inhibitors have been developed that show broad antitumor activity in several different cancers, 55,94,95 and these are currently being evaluated in clinical trials. MTH inhibitors show a similar.
The demonstration that p21 is involved in cell response to DNA damage, mediated through transcriptional activation by p53, was first obtained in mammalian cells [41,42]. The main role of p21 in the G 1 checkpoint resides in its ability to inhibit the activity of cyclin E, and cyclin A/CDK2 complexes required for the G 1 /S phase transition. DNA Repair, Mutagenesis, and Other Responses to DNA Damage by Errol C Friedberg, , available at Book Depository with free delivery worldwide. Responses to Aberrant DNA Replication and DNA Damage in Metazoa Jean Gautier and Jiri Bartek PART III: CELLULAR DNA REPLICATION AND HUMAN DISEASE Chapter DNA Damage and Human Disease Errol C. Friedberg Chapter DNA Polymerases and the Fidelity of DNA Replication Polina V. Shcherbakova and Thomas A. Kunkel Chapter An ideal textbook for advanced undergraduate and graduate students, the book is also an essential resource for all scientists researching cellular responses to DNA damage. Completely reorganized, the new edition presents a significant overhaul of the existing chapters and introduces important new material, reflective of the major changes and Reviews: 4.